New, reasonably fast method to compute the patristic distance between a pair of species in a large tree

A R-sig-phylo questionyesterday read as follows (very slightly paraphrased):

“Given a large newick tree e.g. from the new open tree of life (304959 tips) I want to calculate a pairwise distance between a small subset of species. The tricks I've seen so far [Ed. ape::cophenetic, which computes a N× N patristic distance for a tree with N tips] do not work on a tree of that size. I want to determine single species to single species distances without having an algorithm attempt to calculate the distance for all possible species (which is what ape is doing). Is there a package/trick to accomplish this?”

As a matter of fact, this can be done in a reasonably efficient way using the phytools function fastHeight, which computes the height above the root of the MRCA of any pair of species. That is because, for two species i and j, the patristic distane between them is simply the sum of the heights above the root for species i and j minus two times the height above the root of the common ancestor of i& j.

To show that this works fairly well, let's try to write a little custom function, fastDist, to compute this distance using the heights as mentioned:

library(phytools)
fastDist<-function(tree,sp1,sp2){
    fastHeight(tree,sp1,sp1)+fastHeight(tree,sp2,sp2)-
        2*fastHeight(tree,sp1,sp2)
}

Now, let's test it on a somewhat large tree:

## simulate tree at random
tree<-rtree(n=5000)
sp1<-sample(tree$tip.label)[1]
sp1

## [1] "t941"

sp2<-sample(tree$tip.label)[2]
sp2

## [1] "t2799"

## compute using cophenetic
system.time(d<-cophenetic(tree)[sp1,sp2])

##    user  system elapsed 
##    5.20    0.68    5.96

d

## [1] 11.34199

## compute using fastDist
system.time(d<-fastDist(tree,sp1,sp2))

##    user  system elapsed 
##    0.05    0.00    0.04

d

## [1] 11.34199

Having done that, let's go for broke with a tree of 304,959, just as described:

tree<-rtree(n=304959)
tree

## 
## Phylogenetic tree with 304959 tips and 304958 internal nodes.
## 
## Tip labels:
##  t51258, t83258, t60186, t263493, t117091, t210153, ...
## 
## Rooted; includes branch lengths.

sp1<-sample(tree$tip.label)[1]
sp1

## [1] "t51585"

sp2<-sample(tree$tip.label)[2]
sp2

## [1] "t244730"

## just to check that our MRCA is not the root
fastMRCA(tree,sp1,sp2)

## [1] 427604

## compute using fastDist
system.time(d<-fastDist(tree,sp1,sp2))

##    user  system elapsed 
##    4.80    1.34    6.21

d

## [1] 12.93951

Cool.

Just for the heck of it, I have also added this function to phytools & it is available from GitHub already.